Figure 1. Propagation of indirect eQTL additive effects. (A) Structure of the eQTL network underlying the mixed GMM employed to simulate the data shown on the other panels. Panels (B) to (D) show average estimated additive effects of the eQTL on each gene across 10,000 data sets simulated from different combinations of nominal gene-gene correlations (ρ) and additive effects (a). Gray lines were calculated from all data while black lines recreate the effect of selection bias by using only eQTL associations with LOD > 3.